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    • Upstream Processing 
      Enable stepwise, risk-controlled scale up of microbial bioprocesses, from benchtop through to commercial scale fermentation with flexible capacity that grows alongside your program.
    • Downstream Purification 
      Deliver target yield, purity, and performance through custom downstream solutions, engineered to align with your specifications and optimize every stage of your process for consistent, reliable results.
    • Analytical Testing 
      Ensure confidence at every stage with structured, risk-managed transfer, qualification, and validation of analytical assays for raw material inspection, in-process analysis, and final product release.
    • Formulation & Final Product Processing 
      Streamline production with integrated formulation, bulk lyophilization, and fill-finish services, enabling efficient progression from pilot batches to high-volume output with consistent quality and reliability.
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Upstream Processing

Enable seamless scale‑up from benchtop fermenters to commercial scale
manufacturing across a range of microbial expression systems

Controlled and predictable scale-up,
from benchtop to 14,500L

When bringing your discovery to market, we know how important it is to find a manufacturing partner who gives you confidence and support at every stage. Our upstream bioprocessing capabilities take your program from early-stage development through to
routine commercial manufacture.

Operating from FDA-registered facilities in the U.S., and under ISO 13485:2016 and ISO 9001:2015 certified quality management systems, we deliver fermentation processes aligned with cGMP requirements.

Our fermentation suites are purpose built for microbial production, with dedicated microbiology laboratory to support cell banking and early-stage processing. All our vessels have harmonized aspect ratios to ensure your process scales with control and predictability from day one.

OverviewEquipmentKey benefits

Microbial fermentation expertise across diverse product types

We specialize in microbial fermentation and biologically derived production, supporting a wide range of materials across the product lifecycle:

Expression systems

Bacterial (including E. coli) and yeast platforms

Predictable scale up

Enzymes, recombinant proteins and other biologics

Predictable scale up

Peptides, plasmids, DNA fragments, lipids and complex biomolecules

We can also assess more complex or specialized materials such as in-food grade GMP or plant cell culture-derived materials on a case-by-case basis. This will be subject to an evaluation of process complexity, contamination risk, and facility suitability.

Our 24,000 sq ft manufacturing facility includes segregated upstream suites, enabling multiple processes to run in parallel, with support for both BSL‑1 and BSL‑2 organisms and integrated microbiology capabilities for early-stage development.

ManufacturerEquipmentWorking Volume
EppendorfBioFlo 320 Fermenter1-10L
EppendorfNew Brunswick BioFlo® 610 fermenter65L
EppendorfNew Brunswick BioFlo® 610 fermenter125L
EppendorfNew Brunswick BioFlo® 610 fermenter300L
EppendorfNew Brunswick BioFlo® 610 fermenter1,500L
EppendorfNew Brunswick BioFlo® 610 fermenter3,000L
ABECCustom Built Fermenter14,500L
ABECTemperature controlled media vessels10,000L
ManufacturerEquipmentWorking Volume
EppendorfBioFlo 320 Fermenter1-10L
EppendorfNew Brunswick BioFlo® 610 fermenter65L
EppendorfNew Brunswick BioFlo® 610 fermenter125L
EppendorfNew Brunswick BioFlo® 610 fermenter300L
EppendorfNew Brunswick BioFlo® 610 fermenter1,500L
EppendorfNew Brunswick BioFlo® 610 fermenter3,000L
ABECCustom Built Fermenter14,500L
ABECTemperature controlled media vessels10,000L

Predictable scale up

All fermentation vessels have equivalent aspect ratios to support predictable scale up of bioprocesses.

Stepwise upstream scales

Our sliding scale of fermentation vessels provide you with a stepwise, controlled scale up pathway.

Mobile fermentation vessels

Configure the required seed train for your bioprocesses and maintain processing within the isolated HEPA filtered suites.

Drawer fill

Our custom built ABEC fermentation vessel and media holding tank let you conduct drawer fill fermentations to increase total your production capacity.

Adaptable processing

We support batch fed and standard fermentations and can support with complex feeding strategies.

Flexible production configuration

We offer flexible, bespoke upstream processing to accommodate the requirements of complex microbes.

Partner with Nexus Bioworks for scalable microbial biomanufacturing

Talk to our experts

Partner of choice for microbial bioprocessing

See how our flexible biomanufacturing solutions are helping our clients take their molecules from
discovery to commercial scale manufacture.

Peptide Bioprocessing Scale-Up

Optimising scale-up activities for a fermentation-derived peptide

Read more

E. coli Fermentation Scale-Up

Establishing robust manufacturing capability for a key enzyme

Read more

Anaerobic Fermentation Scale-Up

Accelerating production readiness for an extracellular enzyme

Read more

Related services

Can’t find what you’re looking for? Explore our other services.

Downstream Purification

Analytical Testing

Formulation & Final Product Processing

Partner with Nexus Bioworks for scalable microbial biomanufacturing

Talk to our experts
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Services

Upstream ProcessingDownstream PurificationAnalytical TestingFormulation & Final Product Processing

Partnering

PartneringExperienceAnaerobic FermentationE. coli FermentationPeptide Bioprocessing

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