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    • Upstream Processing 
      Enable stepwise, risk-controlled scale up of microbial bioprocesses, from benchtop through to commercial scale fermentation with flexible capacity that grows alongside your program.
    • Downstream Purification 
      Deliver target yield, purity, and performance through custom downstream solutions, engineered to align with your specifications and optimize every stage of your process for consistent, reliable results.
    • Analytical Testing 
      Ensure confidence at every stage with structured, risk-managed transfer, qualification, and validation of analytical assays for raw material inspection, in-process analysis, and final product release.
    • Formulation & Final Product Processing 
      Streamline production with integrated formulation, bulk lyophilization, and fill-finish services, enabling efficient progression from pilot batches to high-volume output with consistent quality and reliability.
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Downstream Purification

Achieve efficient purification and consistent product quality with
scalable downstream processing solutions tailored to your molecule and
manufacturing goals

Custom purification pathways
designed to meet your product yield
and purity specifications

When bringing your product to market, selecting the right purification strategy is critical to achieving the yield, purity, and consistency required for success. Our downstream processing capabilities support your program from early-stage development through to routine commercial manufacture, with workflows designed around your molecule and
end-product requirement.

Operating from FDA-registered facilities in the U.S., and under ISO 13485:2016 and ISO 9001:2015 certified quality management systems, we deliver downstream processes aligned with cGMP requirements, ensuring quality and compliance at every stage of purification.

Our dedicated temperature-controlled downstream processing suite provides a range of equipment to support all upstream production scales. Our scientists work closely with your team to develop and optimize even the most complex downstream processes, helping you achieve your target product quality and performance specifications.

OverviewEquipmentKey benefits

Microbial purification expertise across diverse product types

We provide comprehensive downstream processing capabilities, supporting every stage of purification from initial harvest through to final product preparation:

Purification technologies

Chromatography (IEX, affinity, HIC), tangential flow filtration (TFF), centrifugation, and microfiltration

Target products

Enzymes, recombinant proteins, and biologically derived macromolecules

We can also assess more complex or specialized purification requirements on a case-by-case basis. This will be subject to an evaluation of process complexity, contamination risk, and facility suitability.

Our 24,000 sq ft manufacturing facility includes segregated processing suites, enabling multiple workflows to run in parallel, with integrated capabilities that support seamless transition from upstream production to downstream purification.

Equipment
AKTA Pilot
AKTA Process
Cell Harvester
Pellicon
Millistak
Equipment
AKTA Pilot
AKTA Process
Cell Harvester
Pellicon
Millistak

Tailored purification strategies

We design bespoke downstream workflows aligned to your molecule’s properties, quality requirements, and commercial goals, ensuring efficient and scalable purification.

High product recovery and yield

Our processes are optimized to maximize recovery while minimizing losses across each purification and concentration step, improving overall process efficiency.

Seamless scale-up

Downstream workflows are developed with scalability in mind, enabling smooth transition from development through to pilot and commercial manufacturing.

Cost-efficient manufacturing

By optimizing unit operations and reducing process complexity, we help lower manufacturing costs while maintaining product quality and consistency.

Integrated upstream-to-downstream expertise

By aligning purification strategies with upstream fermentation processes, we create efficient end-to-end workflows that reduce risk and improve overall manufacturing performance

Partner with Nexus Bioworks for scalable microbial biomanufacturing

Talk to our experts

Partner of choice for downstream purification

See how our flexible biomanufacturing solutions are helping our clients take their molecules from
discovery to commercial scale manufacture.

Peptide Bioprocessing Scale-Up

Optimising scale-up activities for a fermentation-derived peptide

Read more

E. coli Fermentation Scale-Up

Establishing robust manufacturing capability for a key enzyme

Read more

Anaerobic Fermentation Scale-Up

Accelerating production readiness for an extracellular enzyme

Read more

Related services

Can’t find what you’re looking for? Explore our other services.

Upstream Processing

Analytical Testing

Formulation & Final Product Processing

Partner with Nexus Bioworks for scalable microbial biomanufacturing

Talk to our experts
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Services

Upstream ProcessingDownstream PurificationAnalytical TestingFormulation & Final Product Processing

Partnering

PartneringExperienceAnaerobic FermentationE. coli FermentationPeptide Bioprocessing

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